Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 14-007532
- Jacksonville, Florida: 14-007532
NCT ID: NCT02372773
Sponsor Protocol Number: 14-007532
About this study
This study is being done to learn more about normal thinking and behavior, mild thinking and behavior problems, Frontotemporal Dementia and other forms of dementia in families in which one or more relatives have a mutation associated with Frontotemporal Dementia.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Must be a member of family with a known mutation in one of the three major FTLD related genes: MAPT, PGRN, or C9ORF72.
- At least 18 years of age.
- The predominant phenotype in the kindred must be cognitive/behavioral (ie, kindreds in whom parkinsonism or ALS is the predominant clinical phenotype among affected relatives may be excluded)
- Have a reliable informant who personally speaks with or sees that subject at least weekly.
- Subject is sufficiently fluent in English to complete all measures
- Subject must be willing and able to consent to the protocol and undergo yearly evaluations over 3 years.
- Subject must be willing and able to undergo neuropsychological testing (at least at baseline visit).
- Subject must have no contraindication to MRI imaging.
Exclusion Criteria
- Known presence of a structural brain lesion (e.g. tumor, cortical infarct).
- Presence of another neurologic disorder which could impact findings (eg, multiple sclerosis).
- Subject is unwilling to return for follow-up yearly, undergo neuropsychological testing and MR imaging.
- Subject has no reliable informant.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Bradley Boeve, M.D. |
Closed for enrollment |
|
Jacksonville, Fla.
Mayo Clinic principal investigator Neill Graff Radford, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available