Inclusion Criteria:

• 18 years or older
• Confirmed diagnosis of ulcerative colitis (UC) and a history of total abdominal colectomy (TAC) with ileal pouch anal anastomosis (IPAA)
• Closure of ileostomy, with reinstitution of fecal stream through the ileal pouch, at least 3 years prior to enrollment in the study
• Ability to understand study procedures and to comply with them for the entire length of the study.
• Men and women of reproductive capability will be enrolled.  Contraception is not required, although a negative urine pregnancy test will be required in all women immediately prior to participation in the study.  

Exclusion Criteria:

• Female patients who are pregnant (a urine pregnancy test will be performed prior to study procedures)
• Patients who are on blood thinners, unable to hold for 5 days prior to visit 1, per physician
• Inability or unwillingness of individual or legal guardian/representative to give written informed consent.
• Patients with symptoms suggestive of active inflammation (increase in bowel frequency > 3 bowel movements over baseline, bleeding, urgency, or fever > 100.5°F)