Inclusion Criteria:

• Trauma patients who arrive to Mayo Clinic Hospital - Saint Marys Emergency Deparment and are classified as Level Red and Yellow activations.
• Male and female patients 18 years of age or older (no upper age limit).
• Blunt and/or penetrating traumatic injuries.

Exclusion Criteria:

• Are on therapeutic anticoagulation, to include Coumadin/Pradaxa or antiplatelet agents (excluding Plavix, aspirin or ibuprofen).
• Have preexisting coagulopathy (cirrhosis and inherited clotting disorders including Hemophilia A & B, Factor IX, Factor XI deficiencies).
• Patients greater than 12 hours from time of injury.
• Have history of known malignancy (no clinical evidence within 3 months).
• Active diagnosis of sepsis at the time of injury.
• Renal failure on dialysis.
• Patients with thermal injuries ( not including “road rashes”).
• Patients on high dose steroids or autoimmune medications.
• Patients who have experienced traumatic injuries within the past 1 year.
• Known pPregnancy.
• Prisoners.
• Have a preexisting medical condition that, in the judgment of the investigator, would preclude participation in this study.