Inclusion Criteria

• Males or females between the ages of 18 and 70 years
• Must have a diagnosis of mild to moderate dehydration not associated with migraine headache or diabetic ketoacidosis
• Must be free of any disease condition, which in the judgment of the investigator or designee would interfere with the evaluations in the study or impair the patient’s safe participation in the study
• Must be capable of understanding the study and providing informed consent

Exclusion Criteria

• History or evidence of any disease or condition, which in the opinion of the investigator or designee adversely affects the study evaluations or the safety of the patient’s participation in the study
• Any patient for whom the investigator or designee anticipates the possible need for hospitalization
• Any patient who may require I.V. therapy for purposes other than hydration
• Has evidence of migraine contributing to dehydration
• Has dehydration from diabetes mellitus and/or ketoacidosis
• Any history or evidence of congestive heart failure (NYHA ≥ II)
• Any history or evidence of chronic kidney disease (GFR < <60 mL/min/1.73 m2 for at least 3 months)
• Any history or evidence of edema or fluid accumulation syndromes
• Inability to comprehend the study procedures or to understand and sign the Informed Consent
• Any fluid or electrolyte restrictions
• Evidence of significant drug addiction or active use of any drug of abuse
• Intoxicated or evidence of excessive alcohol use
• A history of intolerance or allergy to any of the hydration fluids or other substances used in this study
• A history of allergy or intolerance to Ondansetron
• Currently Pregnant or Nursing
• Evidence suggesting a perforated or obstructed bowel upon examination by the treating clinician
• Prisoners