A Study Using Lactated Ringer's Solution versus 5%Human Albumin in Cardiac Surgery Patients

Overview

About this study

The purpose of this study is to compare the total fluid volume of using 5% human albumin and Lactated Ringer's in the perioperative cardiac surgical patient. Our hypothesis is that the individual total fluid volume will be less with 5% human albumin compared to Lactated Ringer's in the perioperative cardiac surgical patient.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Adult male
  • Non-pregnant female 
  • Elective cardiac surgery
  • Aspirin, heparin, or warfarin preoperatively are accepted

 

Exclusion Criteria

  • Previous sternotomy emergency surgery
  • Combined procedures involving vascular or thoracic operations
  • Congenital heart repair
  • Hypothermic CPB < 28C
  • Serum creatinine 1.5 mg/dL
  • Dialysis dependent renal failure
  • Neurologic injury or event within 30 days (including transient ischemic attack)
  • Cerebrovascular accident with significant residual neurologic deficit
  • Severe chronic obstructive pulmonary disease with FEV1 < 45% of predicted
  • Home oxygen use
  • Previous difficult intubation
  • Acute normovolemic blood conservation techniques
  • Primary liver disease with serum AST > 31 U/L
  • Circulatory arrest
  • Thrombolysis
  • Pre-existing clotting disorder
  • Platelet receptor GPIIb/IIIa antagonists medication received within 48 hours
  • Steroids
  • Left ventricular ejection fraction < 40%
  • Intra-aortic balloon pumps
  • Ongoing congestive heart failure
  • Ventricular assist devices
  • Total heart transplants
  • Pregnant women
  • Adults lacking capacity to consent
  • Any patients initially enrolled in the study that end up with an intra-aortic balloon pump, left ventricular assist device, or on extracorporeal membrane oxygenation will be eliminated from the study

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

William Oliver, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Additional contact information

Non-cancer trials contact form

Phone: 800-664-4542 (toll-free)

International patient clinical studies questions