A Study of the Role of the Forkhead Box O3a BNIP3 Pathway in Human Cardiovascular Disease
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 15-008625
Sponsor Protocol Number: 15-008625
About this study
The purpose of this study is to collect cardiac biopsies and assess the activity of the signaling pathway in patients with cardiovascular disease by using transmission electron microscopy to study mitochondrial structure and morphology and by assessing the biology of the genes and proteins of the FOXO3a effector, BNIP3.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria
- Age 18 or older
- Should have a recent echo, preferably within one to three months prior to surgery
- Diabetic patients: A1C within 1-3 months of enrollment
Exclusion Criteria
- Acute Coronary Syndrome (STEMI or NSTEMI) within the past 6 months
- History of myocarditis or pericarditis, infiltrative or hypertrophic cardiomyopathy
- Severe mitral regurgitation or congenital heart disease
- Prior cardiac surgery
- Any non-cardiac disease or condition that can significantly influence cardiac function
- Advanced renal failure (CKD stage 4-5), chronic anemia (hematocrit < 30), bleeding diathesis
- Any condition that could affect patient’s ability to provide informed consent
- History of alcohol or drug abuse
- Women of child-bearing potential
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Margaret Redfield, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available