Characterizing HIV-related Diastolic Dysfunction
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 16-008091
NCT ID: NCT02860156
Sponsor Protocol Number: Pro00074493
About this study
The purpose of this study is to better understand how the heart’s health and function is affected by HIV infection and use of active antiretroviral therapy.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Age >40 years
- Willingness and ability to provide informed consent
- HIV antibody positive
- On HAART for >6 months (HIV positive cohort only)
- History of adequate viral suppression as defined by HIV RNA level <200 copies/mL in the past 6 months
- LVEF >50% -
Exclusion Criteria:
- Past EF <50%
- Moderate or severe valve stenosis or regurgitation, or past repair or replacement
- Percutaneous or surgical revascularization or active angina
- Persistent atrial fibrillation
- BP>160mmHg SBP or >100mmHg DBP
- Comorbid inflammatory disease (e.g. RA or SLE)
- Active cancer or cancer chemotherapy treatment in the prior year (except skin cancer that did not require chemotherapy or radiation)
- Chronic use of steroids or anti-inflammatory therapy
- GFR <30 mL/min
- Active in a clinical trial with investigational product
- Pregnant or lactating females
- Contraindication to cMR or gadolinium injection (such as severe claustrophobia, metal implants, etc.)
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Margaret Redfield, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available