A Study of Daytime Changes in Corneas with Fuchs Dystrophy
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 16-005843
Sponsor Protocol Number: 16-005843
About this study
The purpose of this study is to determine changes in corneal thickness and backscatter after first morning eye-opening across a range of fuchs endothelial dystrophy severity, and in healthy corneas. Corneal measurements will be made with a Scheimpflug camera and associated changes in visual acuity and glare (forward scatter) will be determined.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria
- Presence of central or paracentral corneal guttae
- Any age, with expected range of 40-90 years
- Any sex or race
- Some normal subjects will be recruited, with normal corneas
- Absence of central or paracentral corneal guttae
- Above 50 years of age to match the predominant age of onset of FECD
- Any sex or race
Exclusion Criteria
- Corneal disease (except Fuchs dystrophy in the Fuchs dystrophy group)
- Previous occular surgery or refractive laser treatment
- Current contact lens wear
- Use of topical medications (except artificial tears) or systemic medications known to affect the cornea
- Glaucoma or occular hypertension
- Systemic diseases known to affect the cornea, e.g. diabetes
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Sanjay Patel, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available