Cardiac Troponin Fragments in Peripartum Cardiomyopathy

Overview

About this study

The primary aim of this study is to measure cardiac troponin (cTn) values with high sensitivity assays in patients with acute peripartum cardiomyopathy (PPCM) in order to determine whether specific fragments exist in these patients. We will also determine whether cTn fragment profile correlates with left ventricular recovery. Finally, we aim to establish a Bio bank in order to facilitate further investigations.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patient Group:
    • Development of cardiac failure in the last month of pregnancy or within 5 months of delivery
    • Absence of an identifiable cause for the cardiac failure
    • Absence of recognizable heart disease prior to the last month of pregnancy
    • LV systolic dysfunction demonstrated by classical echocardiographic criteria: ejection fraction <45% or fractional shortening <30%, or both
  • Control Group:
    • history of acute myocardial infarction

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Lori Blauwet, M.D.

Closed for enrollment

More information

Publications

Publications are currently not available

Additional contact information

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Phone: 800-664-4542 (toll-free)

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