The Influence of Pedal Rate on Activation of Locomotor Afferents and Cardiovascular Responses
Overview
Tab Title Description
Study type
InterventionalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 15-009392
Sponsor Protocol Number: 15-009392
About this study
The first purpose is to determine the influence of pedal rate during constant-load submaximal locomotor exercise on ventilation, gas exchange, blood pressure, and cardiac hemodynamic responses during post-exercise activation of group III and IV locomotor muscle afferents using a novel application and integration of two separate but related scientific questions to better understand peripheral mechanisms of exercise tolerance in humans. The second purpose is to compare ventilation, gas exchange, blood pressure, and cardiac hemodynamic responses across the adult healthy aging spectrum.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Healthy adults (≥18 years of age)
- Nno history of cardiovascular, pulmonary, metabolic, neurologic, orthopaedic, or other diseases affecting the neuromuscular system
- BMI ≤35 kg/m2
- Current non-smokers with smoking history <15 pack years
- Able to engage in exercise (i.e., without orthopedic limitations or musculoskeletal disorders)
Exclusion Criteria:
- History of cardiovascular, pulmonary, metabolic, neurologic, orthopaedic, or other diseases affecting the neuromuscular system
- BMI >35 kg/m2
- current smokers with smoking history ≥15 pack years
- Not able to engage in exercise (e.g., known orthopedic limitations or musculoskeletal disorders)
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Thomas Olson, M.S., Ph.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available