A Study of Oxygen Cost of Exercise in Patients with and without Heart Failure
Overview
Tab Title Description
Study type
InterventionalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 09-008507
Sponsor Protocol Number: 09-008507
About this study
This study is being done to: (1) develop a simple tool to assess breathing muscle performance; (2) measure the oxygen cost of breathing during exercise; (3) measure the respiratory muscle blood flow requirements of hyperpnea during exercise; and (4) to quantify the energy cost of exercise in relation to disease severity.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Heart Failure patients with a history of stable idiopathic dilated or ischemic cardiomyopathy (>1 yr, with >/ =1 episode of congestive failure requiring hospitalization)
- New York Heart Association Class II and III symptoms
- No history of dangerous arrhythmia's
- Not pacemaker dependent
- Less than class II obesity (BMI
- No or minimal smoking history (<15 pk years)
CHF patients with an ejection fraction of less than 40% will be included in the Heart Failure with Reduced Ejection Fraction (HFrEF) group.
- All other CHF patients will be included in the Heart Failure with Preserved Ejection Fraction (HFpEF) group.
Controls will consist of age, gender , and BMI matched subjects
- No history of cardiovascular related abnormalities (i.e. Hx of shortness of breath, chest discomfort, abnormal rest or exercise ECG)
- Non-obese (BMI 20-32)
- No or minimal smoking history (<15 pk yrs)
Exclusion Criteria:
- Unable to engage in exercise testing due to existing comorbidities.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Bruce Johnson, Ph.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available