A Study of Immune Profiling of Blood Samples in Patients with Benign and Malignant Thyroid Disorders
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 13-007101
Sponsor Protocol Number: 13-007101
About this study
The purpose of this study is to perform a comprehensive immunophenotypic analysis of peripheral bloods samples from patients with benign and malignant thyroid disease. This data will be used to determine whether patients with advanced thyroid cancers have significantly altered numbers and/or subtypes of circulating immune cells, in particular immunosuppressive monocytes.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Patients ≥18 of age
- Able to consent at study entry
- Present to endocrinologists and/or endocrine-related clinics (T-NOD or Thyroid Clinic) and/or medical oncology clinic at MCR for the evaluation and/or treatment of thyroid-specified conditions or non-thyroid related cancers (ie melanoma, lung cancer)
- This will include patients who present with thyroid cancer
- Benign thyroid nodules
- Hashimoto’s thyroiditis
- Graves and thyroiditis following immune therapy with ipilimumab, nivolumab and/or pembrolizimuab.
Exclusion Criteria:
- Patients unwilling and/or unable to provide consent
- Patients <18 years-old
- Pregnant patients
- Any patient with active infection(s), fevers and/or immunodeficiency syndrome
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Mabel Ryder, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available