Family Study of Monoclonal B-Cell Lymphocytosis (MBL)

Overview

About this study

Given that family members of CLL patients are known to have an increased risk of CLL (on the order of 8-fold), and they have a higher prevalence of MBL than in an unselected sample of individuals, there is a need to understand the natural course of MBL in individuals from these high-risk families. This information may help us understand which MBL patients are likely to progress to clinical disease. Ultimately, the findings from this study may advance our understanding of the relationship between MBL and CLL, and may result in new approaches for the prevention, early detection, and treatment of CLL.

The scientific aims of our project are as follows:

  • To evaluate the risk of progression from MBL to CLL in individuals from high-risk families.
  • To evaluate environmental risk factors for MBL and progression to CLL.
  • To evaluate germ line genetic changes among individuals with MBL, CLL, and a sample of controls.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Consented participants in IRB study 489-04, Genetic Epidemiology of B-Cell Lymphoproliferative Disorders.
  • History of MBL if not in study 489-04.

Exclusion Criteria:      

  • Is unable to understand English and/or complete the informed consent form.

Eligibility last updated 8/20/21. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Susan Slager, Ph.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Susan Slager Ph.D.

(507) 284-5965

Slager.Susan@mayo.edu

More information

Publications

Publications are currently not available

Additional contact information

Cancer-related trials contact form

Phone: 855-776-0015 (toll-free)

International patient clinical studies questions