A Study to Assess Changes of Heart Function and Aortic Stiffness in Relation to Intra-dialytic Hypotension

Overview

About this study

Our aim is to analyze changes in global and/or regional myocardial mechanics of the left and right ventricle before and after hemodialysis.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients in Mayo clinic outpatient dialysis center who receive hemodialysis for more than 3 months 
  • Sign a written informed consent for research purposes will be screened for recruitment.

Intra-dialytic Hypotension (IDH) Group:

  • Patients present symptomatic intra-dialytic hypotension (IDH), defined as a drop in systolic blood pressure ≥ 20 mmHg or a decrease in MAP by ≥ 10mmHg with associated symptoms.
  • Symptomatic intra-dialytic hypotension (IDH) occur in at least one-third of the dialysis sessions during the 3 months prior to this study.

Daily Dialysis Group:

  • Patients on daily hemodialysis without intra-dialytic hypotension (IDH)

Regular Dialysis Group:

  • Patients on chronic hemodialysis 3 times per week without intra-dialytic hypotension (IDH)

Exclusion Criteria:

  • Previous well-known heart failure (EF<50%) 
  • History of heart transplantation 
  • Congenital heart disease 
  • Arrhythmia 
  • Significant valvular disease 
  • Pacemaker dependent 
  • Poor echo window

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Hector Villarraga, M.D.

Closed for enrollment

Contact information:

Hector Villarraga M.D.

(507)284-1446

More information

Publications

Publications are currently not available