A Study to Establish Novel Tumor Models Using Scant Tumor Specimens from Solid Tumor Patients
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 17-003174
- Scottsdale/Phoenix, Arizona: 17-003174
Sponsor Protocol Number: 17-003174
About this study
The objective of this research is to determine the feasibility of establishing organoid tumor models using scant solid tumor tissues obtained by image-guided core needle biopsy procedures during routine clinical care. The routine clinical biopsy may be by image-guidance, endoscopic-guidance (e.g., EGD, colonoscopy, bronchoscopy), direct visualization (e.g., skin biopsy) and surgical exploration. Once established, the tumor organoids’ response to anti-cancer agents will be assessed. If proven feasible, this technique can potentially be integrated into routine clinical care of solid tumor patients and help guide the treatment of the donor patient in the clinic.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Patient must have cytologically or histologically confirmed solid tumor.
- Should be undergoing biopsy procedure as part of routine clinical care, or whom have consented to collect fresh tissue biopsy.
- Age 18 years and above.
Exclusion Criteria:
- Patients who will be undergoing fine-needle aspiration (FNA) biopsy are excluded.
- Woman known to be pregnant is excluded.
Eligibility last updated 3/1/22. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Wen Wee Ma, M.B.B.S. |
Closed for enrollment |
|
Scottsdale/Phoenix, Ariz.
Mayo Clinic principal investigator Tanios Bekaii-Saab, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available