Inclusion Criteria:

1. Has diabetes mellitus with symptoms of gastroparesis and previously documented gastric emptying delay or previously documented idiopathic gastroparesis in the last 5 years.
2. Has a body mass index (BMI) greater than or equal to (≥) 16 and less than or equal to (≤) 40 kilogram per meter square (kg/m^2) at the Screening Visit.

Exclusion Criteria:

1. Have glycosylated hemoglobin (HbA1c) greater than (>) 12 percent (%).
2. Have other structural diseases/conditions that affect the gastrointestinal (GI) system.
3. Are unable to withdraw drugs known to alter GI transit 48 hours prior to the study.
4. Have clinically significant abnormal baseline safety laboratory values.
5. Have clinical evidence of significant cardiovascular, respiratory, moderate or severe renal insufficiency, hematological, neurological, or psychiatric disease, or other disease that interferes with the objectives of the study.
6. Have preexisting hepatic disease that meets Child-Pugh Class B (moderate; total score 7 to 9 points) or C (severe; total score 10 to 15 points).
7. Are without known preexisting hepatic disease who have 1 or more of the following:
   • AST or ALT >2 times the upper limit of normal (ULN).
   • Bilirubin >1.5 times the ULN unless due to Gilbert's syndrome.
   • International normalized ratio (INR) >1.5 unless on anticoagulation therapy.
8. Have QT intervals with Fridericia correction method (QTcF) (QT corrected based on Fridericia's equation) interval ≥ 460 millisecond (msec) or with other factors that increase the risk of QT prolongation or arrhythmic events at screening. Note: Participants with bundle branch block and a prolonged QTc interval should be reviewed by the Medical Monitor for potential inclusion.
9. Have cardiac history that includes conditions requiring heart rate control (example, atrial fibrillation, atrial flutter).
10. Have second or third degree AV block; AV disassociation; >5 beats of non-sustained VT at a rate >120 beats per minute (bpm); Electrocardiogram (ECG) changes consistent with acute myocardial ischemia or infarction.
11. If female, are pregnant or lactating or intending to become pregnant before participating in this study, during the study, and 4 to 5 days (5 half-lives) PLUS 30 days after last dose of the study drug; or intending to donate ova during such time period.
12. Are considered by the investigator to be alcoholics not in remission or known substance abusers. Have a history of alcohol consumption exceeding 2 standard drinks per day on average (1 glass is approximately equivalent to: beer [354 milliliter per [mL/] 12 ounces], wine [118 mL/4 ounces], or distilled spirits [29.5 mL/1 ounce] per day).