Inclusion Criteria:

• Age ≥ 4 years.
• Able to use computer for assessment battery.
• Receiving cranial photon- or proton-based radiation for primary central nervous system malignancy.
• Histological or radiologic confirmation of intracranial disease.
• ECOG Performance Status (PS) 0-2, Karnofsky PS 60-100, or Lansky/Play PS for Children 60-100.
• Ability to complete clinical quality of life questionnaire(s) by themselves or with assistance.
• Demonstrates the capacity to sign informed consent.
• Willing to sign consent onto the Mayo Clinic Radiotherapy Patient Outcomes Registry and Biobanking study, IRB number 15-000136*, **
  • * Patients do not need to agree to Registry blood draw.
  • **Patients at Mayo Clinic  Florida and Arizona can be enrolled without concurrent Registry consent.   

Exclusion Criteria:

• Patients with WHO Grade IV astrocytoma or glioblastoma tumors.
  • Note: A patient with Grade IV tumors of other histology can participate in the study if they meet all other criteria.
  • Note: Diffuse Astrocytomas with molecular  features of glioblastoma are acceptable on study
• Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection,  symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Any prior intracranial radiation.
• Patients receiving Gamma Knife radiosurgery.