Inclusion Criteria:

• ≥ 18 years of age.
• Male or Female.
• Consultation with a thoracic surgeon.
• Discharge from the hospital with a chest tube and valve in place.
• Subject is able to understand the study procedures and provide informed consent.

Exclusion Criteria:

• Pregnancy.
• Allergy to cephalexin or clindamycin.
• Special consideration should be taken in enrolling subjects with preexisting conditions that can be exacerbated by antibiotic use but are allowed at the discretion of the treating physician.
• Considerations include but are not limited to:
  • C. difficile;
  • Colitis;
  • Impaired renal function;
  • Hypersensitivities to cephalosporins, penicillins, or lincomycin;
  • Hepatic impairment;
  • Anticoagulation therapy;
  • Metformin usage;
  • Probenecid usage.