A Study to Assess a New Personalized Tool for Colorectal Cancer Peritoneal Disease Treatment
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 19-004196
Sponsor Protocol Number: PDO-01
About this study
The objectives of this study are to genomically characterize patient-derived organoids (PDOs) and primary tissues from colorectal peritoneal cancer (CRC) disease, to evaluate the use of PDOs as a new personalized therapy selection tool for intraperitoneal therapy in CRC peritoneal disease, and to evaluate the use of PDOs as a new personalized therapy selection tool for systemic therapy in CRC peritoneal disease.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Age ≥ 18 years old.
- Metastatic CRC patients with synchronous or metachronous peritoneal metastasis.
- Patients who plan to undergo either diagnostic laparoscopy with tissue biopsy of the peritoneal metastases or cytoreductive surgery of the peritoneal metastases as part of routine clinical care.
- Patients willing to consent for biopsy.
Exclusion Criteria:
- Patients who will not have tissue biopsy from diagnostic laparoscopy or tumor resection from cytoreductive surgery as part of routine clinical care.
- Women known to be pregnant.
- Non-English speaking, students, prisoners.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
Contact |
Rochester, Minn.
Mayo Clinic principal investigator Hao Xie, M.D., Ph.D. |
Closed for enrollment |
Contact information:
Cancer Center Clinical Trials Referral Office
(855) 776-0015
|
More information
Publications
Publications are currently not available