Inclusion Criteria:

- The subject, or the subject's legally acceptable representative is willing to participate in a clinical trial, provides written informed consent, and subject
provides written assent, as required by the Mayo Clinic Institutional Review Board (IRB) policy involving human subjects. In the event of subject lacking the capacity or
losing the ability to consent, consent will be deferred to subject's legally acceptable representative

- Subjects that satisfy one of the following diagnostic criteria:

- Patients with established clinical diagnoses of biopsy-proven high-grade glioma and epilepsy refractory to at least 1, drug with a seizure frequency of at least 1 seizure episode per month prior to baseline visit.

- Subjects with body weight of >= 40 kg and =< 125 kg at screening.

Exclusion Criteria:

- Subject has serious cardiac, respiratory, renal, gastrointestinal, hematologic or other medical condition as determined by the investigator to potentially interfere
with the study

- Subjects with glioblastoma not following Stupp protocol for treatment of glioblastoma

- History of status epilepticus in the 6 months prior to screening or a history of seizure clusters progressing to status epilepticus

- Clinically significant suicide risk as determined by the clinician

- Positive test result for drugs of abuse at baseline without documented history of stable use for medical purposes or past medical history of drug and/or alcohol abuse

- Pregnant or breast-feeding

- Subjects treated with PER prior to baseline

- Prior felony conviction disclosed by the patient or previously stated in medical record

- History of violent behavior

- Clinically significant laboratory abnormality at screening or baseline visits, as determined by the investigators

- Use of an investigational drug or device within 20 days prior to treatment day 1

- Repeated radiation therapy for tumor regrowth

- Subjects that plan to undergo tumor resection on or after baseline visit

- Uncontrolled psychiatric disorder at baseline

- Subjects who report active suicidal attempts or suicidality including subjects with a history of suicide attempts or suicidality determined to be clinically significant by
investigators at screening

- Biopsy proven high-grade glioma established 3 months prior to enrollment

Eligibility last updated 5/4/23. Questions regarding updates should be directed to the study team contact.