Inclusion Criteria:

• Ages 21-85 years old.
• Males and females.
• Acute myocardial infarction (ST elevation at the J point in at least 2 contiguous leads of ≥ 2 mm (0.2 mV) in men or ≥ 1.5 mm (0.15 mV) in women in leads V2–V3 and/or of ≥ 1 mm (0.1 mV) in other contiguous chest leads or the limb leads) .
• Successful stent implantation within 4 and 12 hours from onset of AMI symptoms.
• Angiographic evidence of TIMI 0 or TIMI 1 flow through culprit lesion prior to stent placement.
• Angiographic evidence of residual stenosis visually < 30%after stent placement.
• Willing and able to provide signed informed consent.

Exclusion Criteria:

• Prior solid organ transplantation at any time.
• Pregnant or lactating at screening.
• Known presence of chronic systemic inflammatory disorder that requires ongoing therapy with immunosuppressive agents.
• Known immune system compromise including but not limited to human immunodeficiency virus (HIV), hepatitis A, hepatitis B (HBV) or hepatitis C (HCV) infection.
• Known history of malignancy of any type except non-melanoma skin cancer.
• Known serum creatinine > 2 mg/dL or GFR ≤ 30 mL/min within the last twelve months.
• Known AST, ALT, and/or bilirubin (total) elevated twice the upper limit of normal for age & gender within the last twelve months.
• Known Hemoglobin lower than 8.0 g/dL within the last twelve months.
• Known current illicit drug use at screening.
• Other major surgical procedure or major trauma within the previous 14 days prior to enrollment.
• Female of childbearing potential who is unwilling to agree to use acceptable contraception methods for 3 months after receiving the investigational drug.
• Pacemaker/ICD implant in place.
• Adult lacking decision-making capacity.
• Prisoner.
• Non-English speaking.
• English-speaking but illiterate.
• Legally blind.
• Known allergy to heparin or heparin-induced thrombocytopenia.
• Known history of positive SARS-CoV2 testing within the last 30 days.
• DNR/DNI status prior to PCI procedure or planned DNR/DNI status after PCI procedure.
• Homeless or no permanent address at the time of enrollment.

Eligibility last updated 6/13/23. Questions regarding updates should be directed to the study team contact.