Inclusion Criteria:

• Males and females.
• 18 years of age or older.
• Treatment naive patient who is under BE surveillance or is presenting for dysplasia confirmation or initial treatment.
• Patient is able and willing to provide written informed consent.
• Patient has fasted per institutional guidelines.

Exclusion Criteria:

• Significant esophageal fistula or stricture requiring dilation.
• Symptoms of dysphagia.
• Suspicion or known history of gastrointestinal obstruction or mass, varices, rings or webs.
• Known tortuous esophageal/GEJ anatomy.
• Any prior esophageal treatment (e.g., ablation, dilation, surgery, etc.).
• Known inability to swallow pills and capsules, or history of a swallowing disorder (e.g., odynophagia, scleroderma, achalasia, esophageal stricture, or esophageal diverticulum.
• Current diagnosis of cancer.
• Patients for whom use of the Nvision VLE device would be in conflict with the Instructions for Use (IFU).
• Other major medical illnesses (e.g., unstable cardiovascular disease, end-stage liver or kidney disease, recent or suspected active GI bleeding).
• Patients who require anticoagulants.
• Patients who are known to be pregnant.
• Patients who are enrolled in a competing clinincal study.
• Patients for whom the physician feels would not be a good candidate to participate (physician discretion).