A Study to Evaluate Cardiopulmonary Exercise Testing in Liver Transplant Candidates
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Scottsdale/Phoenix, Arizona: 19-011451
Sponsor Protocol Number: 19-011451
About this study
The purpose of this study is to determine agreement between cardiopulmonary exercise testing and cardiac stress testing (SOC) for the identification of subclinical coronary artery disease in liver transplant candidates, to determine agreement between cardiopulmonary exercise testing and dobutamine stress echocardiogram (SOC) for the identification of cirrhotic cardiomyopathy in liver transplant candidates, and to determine agreement between peak oxygen consumption from cardiopulmonary exercise testing and the liver frailty index or the six-minute walk test (SOC), for the identification of frailty in liver transplant candidates.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Patients 50 - 70 years old.
- Waitlisted patients with cirrhosis or those undergoing LT evaluation at the Mayo Clinic, Arizona Liver Transplant Center.
Exclusion Criteria:
- Patients under 50 and over 70 years old.
- Patients with platelets < 30,000, INR > 3, GFR < 30, left main coronary stenosis, moderate/severe stenotic valvular disease, atrial fibrillation and other arrhythmias, resting ventricular ejection fraction < 50%, portopulmonary hypertension, severe COPD, or an exercise contraindication.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Scottsdale/Phoenix, Ariz.
Mayo Clinic principal investigator Elizabeth Carey, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available