A Study to Evaluate Placental Pathologies Using Ultrasound of the Human Placenta

Overview

About this study

The purpose of this study is to develop an ultrasound method to identify villitis of unknown etiology (VUE)-induced inflammation in the human placenta during gestation. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Registration – Inclusion Criteria IUGR Cohort:

  • Age ≥ 18 and ≤ 45 years at study entry.
  • Diagnosis of IUGR before admission to labor and delivery.
  • Ability to provide written informed consent.
  • Weight greater than 110 pounds (50 kilograms, a standard requirement in obstetrics studies that include blood draws).
  • > 28 weeks gestation.

Registration – Inclusion Criteria Control Cohort:

  • Age ≥ 18 and ≤ 45 years at study entry.
  • No known pregnancy complications at obstetrics visit (+/- 1 week gestational age of IUGR cohort).
  • Ability to provide written informed consent.
  • Weight greater than 110 pounds (50 kilograms, a standard requirement in obstetrics studies that include blood draws).
  • > 28 weeks gestation.

Registration – Exclusion Criteria:

  • Known immunodeficiency.
  • Chronic, active viral infections, including HIV-1/2, HTLV-1/2, hepatitis B/C.
  • Known autoimmune disease (e.g., rheumatoid arthritis or systemic lupus erythematosus).
  • Solid organ or transplant recipient.
  • Multiple gestations.
  • Not planning on delivering at Mayo Clinic.
  • Ruptured membranes.
  • < 28 weeks gestation.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Mauro Schenone, M.D.

Closed for enrollment

Contact information:

Maureen Lemens C.C.R.C.

(507) 293-1487

Lemens.Maureen@mayo.edu

More information

Publications

Publications are currently not available