Inclusion Criteria

• Patient must have evidence of a genetic condition or a suspected genomic disorder for which previous testing has not provided a diagnosis, or be a biological family member of such a patient.
• Patient/family member is willing to undergo session(s) with a genetic counselor (GC).
• Patient must understand and provide written informed consent and HIPAA authorization prior to initiation of any study-specific procedures. For a pediatric patient and patient without capacity to consent for him/herself, parents or legal guardians must understand and provide written informed consent and HIPAA authorization prior to initiation of any study-specific procedures.
• Participants of any age are eligible to participate.
• Pregnant women may participate in this research study.Should research results be returned that would have implications for offspring the participant will be offered genetic counseling.

     Exclusion Criteria

• Patient who has an uncontrolled concurrent illness including psychiatric illness, or situations that would limit compliance with the study requirements or the ability to willingly give written informed consent, and who does not have a legal guardian who will take responsibility for ensuring compliance with study requirements and can provide consent on his/her behalf.
• Family member participants will not be eligible for research study if the proband/surrogate declines participation.