A Study of Tricuspid Regurgitation Absence in Pulmonary Hypertension
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Jacksonville, Florida: 13-006084
Sponsor Protocol Number: 13-006084
About this study
The purpose is to study the correlation of right ventricular strain by tissue Doppler and Tricuspid Annular Plane Systolic Excursion (TAPSE) in patients without a tricuspid regurgitation jet with the presence and severity of pulmonary artery hypertension diagnosed by right heart catheterization. The primary aim is to determine the correlation of other echocardiographic, laboratory and clinical findings in patients without a tricuspid regurgitation jet with the presence and severity of pulmonary artery hypertension diagnosed by right heart catheterization. As such, one goal is to potentially create a predictive score with adequate sensitivity to determine which patients without a tricuspid regurgitation jet should have a confirmatory right heart catheterization based on other clinical and echocardiographic findings. Secondary aims include the a determination frequency of an absent tricuspid regurgitation jet by echocardiography in patients with pulmonary arterial hypertension in a single center PH Clinic.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Age 18-85
- Referred for echocardiography with no tricuspid regurgitation jet but a high clinical suspicion for PAH, based on risk factor assessment7, clinical symptoms, and review by PH expert.
Exclusion Criteria:
- Younger than 18 years old or older than 85 years old.
- Patients unable or unwilling to have a right heart catheterization.
- Previously confirmed PH diagnosis by RHC.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Jacksonville, Fla.
Mayo Clinic principal investigator Charles Burger, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available