Inclusion Criteria

• Patients at ages 18 to 99 years old; and
• Venipuncture is feasible (health, access and/or tolerability) for requested blood sample(s).
• Individuals have agreed to participate and signed the study informed consent form; and one of the following criteria:
  • Individuals diagnosed with suspected or being screened for hereditary cancer syndromes using standard clinical, genetic testing, endoscopic, radiological and histological criteria.
  • Patients agreeing to undergo cancer genetic testing as part of their clinical care after discussion with their physician.  
  • Individual with early onset cancers (i.e., any cancer diagnosis under 70 years of age).
  • Individuals with multiple primary cancers suggestive of a hereditary cancer syndrome.
  • Individuals with a strong family history of gastrointestinal, breast, ovarian, endometrial cancers suggestive of a hereditary cancer syndrome.
  • Individuals referred to and being seen in the cancer clinics at Mayo Clinic Arizona.
  • Family members of individuals with hereditary cancer syndromes being seen in the cancer clinic practice at Mayo Clinic Arizona.
  • Patients undergoing surgery at Mayo Clinic Arizona for hereditary cancer syndrome indications.
  • Patients with a hereditary cancer syndrome having upper or lower GI endoscopic procedures for routine care at Mayo Clinic Arizona.

Exclusion Criteria:

• Individuals who do not meet study inclusion criteria.
• Individuals who have not agreed to participate and have not signed the study consent form.