A Study to Evaluate the Effectiveness of Select Beta-lactam Antibiotics in ICU Patients

Overview

About this study

The purpose of this study is to observe and characterize the pharmacokinetics of anti-pseudomonal beta-lactam antibiotics (cefepime, piperacillin/tazobactam, meropenem) in critically ill adults..

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults greater than or equal to 18 years of age.
  • Admitted to an intensive care unit.
  • Treated with either cefepime, piperacillin/tazobactam or meropenem at a consistent dose and interval for at least 36 hours.
  • Must have preexisting intravenous access for routine care that can be accessed for study blood sampling.
  • Subject and/or legally authorized representative are able to provide informed consent.
  • Must have preexisting intravenous access for study blood sampling.

Exclusion Criteria:

  • Individuals < 18 years of age.
  • Individuals without intravenous access for study blood sampling.
  • Individuals whose antibiotic dose and interval varied.
  • Individuals who received more than one dose of the study antibiotic prior to ICU admission.
  • Receiving renal replacement therapy or extracorporeal membrane oxygenation.
  • Individuals with acute kidney injury or an estimated creatinine clearance < 20mL/min.
  • Prior enrollment in the study.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Erin Barreto, Pharm.D., R.Ph.

Closed for enrollment

Contact information:

Erin Barreto Pharm.D., R.Ph.

(507) 255-5732

Barreto.Erin@mayo.edu

More information

Publications

Publications are currently not available