Inclusion Criteria - CRSwNP:

• Age 18 years and older.
• Both males and females.
• Meet clinical definition of CRS which is 12 weeks with at least 2 of the major criteria for diagnosis within the past 24 months (nasal discharge, nasal obstruction, facial congestion, facial pain-pressure-fullness or decrease in sense of smell).
• Presence of nasal polyps as evidenced by a CT scan or rhinoscopy.

 Inclusion Criteria - wsf AERD aspirin desensitization

• Age 18 years and older.
• Both males and females.
• Be Aspirin sensitive (AERD)
• AERD - Meet clinical definition of aspirin exacerbated respiratory disease as identified through clinical history and/or prior positive aspirin intolerance and scheduled to undergo an aspirin challenge and desensitization in the allergic diseases clinical laboratory.

Inclusion Criteria - AERD non-Aspirin desensitization:

• Age 18 years and older.
• Both males and females.
• Meet clinical definition of aspirin exacerbated respiratory disease as identified through clinical history and/or prior positive aspirin intolerance.
• Contraindication to Aspirin therapy or by patient choice.

Exclusion Criteria - All Groups:

• Cystic fibrosis.
• Known pregnancy at the time of appointment.
• Cigarette smoking in the last 6 months.
• Common Variable Immunodeficiency Disease.
• EGPA or small vessel vasculitis.
• Primary ciliary dyskinesia.
• Primary immune deficiency disorder.
• Oral corticosteroids in the past 2 weeks before visit.
• Intramuscular corticosteroids in the past 6 weeks before visit.
• Current cancer treatment with immunotherapy and chemotherapy.
• Treatment with biologics at the time of enrollment.
• Zileuton.

Eligibility last updated 12/20/21. Questions regarding updates should be directed to the study team contact.