A Study to Evaluate Low Dose Chest CT vs. Standard CT in Cystic Fibrosis Patients
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 20-008230
About this study
The purpose of this study is to determine the lowest radiation dose that allows interpretation of chest CT scan.
Our group developed a novel chest CT technology with reduced radiation exposure and procedure duration. This is a new dose optimization and efficiency technology and a tin filter, which greatly reduce the radiation dose compared to a standard chest CT. The procedure is fast and can be performed without sedation. We therefore aim to validate this promising technology as an alternative clinical monitoring tool against current standard-of-care with CXR.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Children, 1-17 years of age.
- Presence of Cystic Fibrosis (CF):
- Sweat tests > 60mEq/L or presence of 2 CF causing mutations;
- Non-CF bronchiectasis or other clinical indications for chest CT;
- Patients who did not sign Minnesota research authorization will be contacted by study PI and phone consent will be obtained.
Exclusion Criteria:
- Over 17 years of age.
- Acute respiratory distress.
- Unstable cardiovascular status.
- hypoxia (SaO2 less than 93% in room air).
- Pneumothorax.
- Pulmonary edema.
- Pulmonary emboli.
- Fractured ribs or other chest trauma.
- Recent bronchoscopy.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Nadir Demirel, M.D., M.S. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available