Ovarian Axis Hormones and Adrenal Androgens and Measurements of Satiation, Postprandial Satiety, and Hunger in Pre- and Post-menopausal Women
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 22-004063
About this study
The purpose of this study is to determine the correlation between ovarian axis hormones and adrenal androgens and changes in satiation, postprandial satiety, and hunger in pre- and post-menopausal women. Since differential hormone profile is considered an important underlying physiologic change through the menopausal transition, changes in ovarian sexual hormones and adrenal androgen levels may have an association with changes in satiation, postprandial satiety, and hunger.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Premenopausal group
- Age 40-48 at the time of original study recruitment.
- Regular menstrual periods for at least 1 year on no hormonal contraception at the time of their participation in the original study.
Postmenopausal group
- Age 52-60 at the time of original study recruitment.
- Confirmed menopausal status at the time of their participation in the original study: no menstrual periods for at least 1 year (but no more than 2 years).
Exclusion Criteria:
- History of hysterectomy.
- History of surgical, chemical, or radiation-induced menopause (i.e., oophorectomy, aromatase inhibitors, chemotherapy for cancer treatment, or radiation therapy).
- Use of any drug that can affect estrogen production or signaling (e.g., GnRH agonists and antagonists, estrogen receptor modulators, etc.).
- Use of systemic estrogen and/or progesterone (oral contraceptives, contraceptive implants, hormone replacement therapy).
- Use of non-hormonal contraceptive methods that can affect the regularity of menstrual cycles (e.g., intrauterine devices).
- History of hypothalamic or pituitary disease (e.g., pituitary adenomas, empty sella, pituitary surgery, hypothalamic masses).
- Patients who denied future use of biological samples or further contact from the previous listed IRBs.
Eligibility last updated 4/18/22. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
More information
Publications
Publications are currently not available