Inclusion Criteria:

• Patients must understand and provide written informed consent prior to initiation of any study-specific procedures.
• ≥ 18 years of age.
• Patients must have a diagnosis of confirmed malignancy.
• Patient is a good medical candidate for a standard of care or research biopsy or surgical procedure to obtain tissue or has tissue available for analysis that has been collected within 12 months of signing consent.

 Exclusion Criteria:

• Uncontrolled concurrent illness including psychiatric illness, or situations that would limit compliance with the study requirements or the ability to willingly give written informed consent.
• Inaccessible tumor for biopsy or patient does not have tumor tissue available for research use.
• Biopsy must not be considered to be more than minimal risk to the patient.
• Contraindications to percutaneous biopsy:
  • Significant coagulopathy that cannot be adequately corrected;
  • Severely compromised cardiopulmonary function or hemodynamic instability;
  • Lack of a safe pathway to the lesion;
  • Inability of the patient to cooperate with, or to be positioned for, the procedure.

Eligibility last updated 11/10/21. Questions regarding updates should be directed to the study team contact.