Validation of MarkVCID in the General Community

Overview

About this study

The purpose of this study is to evaluate and compare the clinical usefulness of plasma and MRI-based MarkVCID biomarkers in relation to age, sex, systemic vascular health, race, ethnicity and cognition.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Male or female.
  • Aged 60 to 90 years, inclusive at Visit 1 Screen.
  • Clinical diagnosis of normal cognition, subjective cognitive decline, mild cognitive impairment or mild dementia ( CDR® ≤ 1.5).
  • Fluent in English or Spanish.

Exclusion Criteria:

  • Contraindications to MRI such as inability to fit inside the MRI scanner, difficulty with close or confined spaces or presence of MRI non-compatible implants such as pacemakers or aneurysm clips.
  • History of or current neurologic, psychiatric or medical disease that could confound the results of the study tests and procedures.
  • Clinical diagnosis of moderate or severe cognitive impairment or dementia, requiring assistance with basic activities of daily living.

Eligibility last updated 2/17/22.  Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ronald Petersen, M.D., Ph.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Alzheimer's Disease Research Center

(507) 284-1324

Jacksonville, Fla.

Mayo Clinic principal investigator

Gregory Day, M.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Memory Disorder Clinic

(904) 953-2677

More information

Publications

Publications are currently not available