Inclusion Criteria:

• Age ≥ 60 years old at time of consent.
• Concurrent enrollment in the Alzheimer’s Disease Research Center (ADRC, Mayo IRB 712-98) and/or Mayo Clinic Study of Aging (MCSA, Mayo IRB 14-004401).
  • Note: Participants may be but are not required to be concurrently enrolled in Brain Amyloid Imaging with Pittsburgh Compound B in Normal Aging, Mild Cognitive Impairment and Dementia (PiB, Mayo IRB 08-005553).  
• Normal cognition to moderate severity Alzheimer’s disease dementia (CDR ≤ 2) or vascular dementia.
• Participants with mild cognitive impairment or dementia must have a care partner or LAR to assist them with the WP setup and the questionnaires,

Exclusion Criteria:

• History of or current non-Alzheimer’s or vascular dementia, such as dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), normal pressure hydrocephalus (NPH) dementia or undetermined cause dementia.
• Major neurological condition (i.e., non-lacunar stroke, TBI, epilepsy, tumor, CNS infection, demyelinating disease, neurodegenerative disease), severe autonomic failure (pure autonomic failure or autonomic neuropathy), major psychiatric disease (i.e., alcohol/drug abuse and schizophrenia),
• Current treatment of OSA. Diagnosed but untreated OSA is acceptable.
• Use of short-acting nitrates within 3 hours of the sleep study.
• Use of selective α1-adrenergic receptor antagonists, for example, tamsulosin (Flomax®), doxazosin (Cardura®), prazosin (Minipress®), and terazosin (Hytrin®) and nonselective α1 and α2 blockers (pentholamine and phenoxybenzamine)
• Finger deformity that precludes adequate sensor application
• Placement of a permanent pacemaker
• Persistent atrial fibrillation or other sustained non-sinus cardiac arrhythmias
• Severe peripheral vascular disease (e.g., status post stent or by-pass surgery in one of the limbs, faint/absent pulses)
• Status post bilateral cervical or thoracic sympathectomy
• Acute lung or heart disease (e.g., decompensated COPD or heart failure).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/29/23.  Questions regarding updates should be directed to the study team contact.