Treating Highly Sensitized Patients on the Kidney Transplant Waiting List by Depleting Their B-cells Using Chimeric Antigen Receptor T Cells (CAR-T)
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Jacksonville, Florida: 22-007826
About this study
The purpose of this study is to decrease the waiting time on the transplant list for patients who have high level of anti-HLA antibodies with ESRD and improve the patients and allograft survival after transplant.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
We will treat the blood samples, in vitro, that are obtained from 10 adult patients listed for kidney, heart or lung transplant at Mayo clinic transplant center and:
- Adult patients 18 years of age and above
- Willing to sign informed consent.
- Highly sensitized with cPRA of 98% and greater
- Willing to provide clinical data and blood samples.
Exclusion Criteria:
We will exclude:
- Any patients who received a desensitization therapy including any monoclonal antibodies, plasmapheresis, and/or splenectomy
- Inability to understand and sign informed consent.
Eligibility last updated 10/14/22. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Jacksonville, Fla.
Mayo Clinic principal investigator Tambi Jarmi, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available