Right Ventricular and Physiologic Cardiac Pacing on Left Ventricular Systolic and Diastolic Function by Cardiopulmonary Exercise Testing to Treat Normal Baseline Left Ventricular Ejection Fraction

Overview

About this study

Right ventricular (RV) pacemaker dependent patients without left ventricular (LV) systolic or diastolic dysfunction at baseline will demonstrate worse LV diastolic and systolic function and pulmonary gas exchange reserve during exercise stress compared to patients with physiologic pacing.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Males or females, age ≥ 20 and ≤ 80 years old.
  • Baseline LVEF ≥ 50%.
  • Normal LV filling pressure.
  • Pacemaker dependent.

Exclusion Criteria: 

  • Prior history of heart failure.
  • Significant valvular heart disease.
  • RV dysfunction.
  • Persistent or chronic atrial fibrillation.
  • Cardiomyopathies.
  • Congenital heart disease.
  • Primary pulmonary hypertension.
  • Active malignancy.
  • Inadequate echo image quality.
  • Unable to perform symptom limited bicycle stress.
  • Significant lung disease.
  • Unable or unwilling to provide consent.

Eligibility last updated 2/1/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Tasneem Naqvi, M.B.B.S., M.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Alexander Esmeralda-Meckelburg

(480) 301-4416

Meckelburg-Cintron.Alexander@mayo.edu

More information

Publications

Publications are currently not available