Pars Plana Vitrectomy Effect on Ocular Biomechanics and Aqueous Humor Dynamics

Overview

About this study

The purpose of this study is to evaluate outflow facility and ocular biomechanical properties in vitrectomized eyes compared to fellow non-vitrectomized eyes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria: 

  • ≥ 18 years of age.
  • Status post unilateral uncomplicated pars plana vitrectomy for epiretinal membrane or internal limiting membrane peel (i.e. for epiretinal membrane, vitreomacular traction, lamellar or macular hole).
  • The same phakic status in the fellow eye.

Exclusion Criteria: 

  • Prior diagnosis of glaucoma, glaucoma suspect, or ocular hypertension.
  • Difference in lens status between the two eyes (phakic, pseudophakic, or aphakic).
  • Preoperative anisometropia greater than 2.5 diopters.
  • Current use of topical, oral, inhaled, injected, or other corticosteroids.
  • Abnormalities of the iridocorneal angle, including neovascular glaucoma, ICE syndrome, peripheral anterior synechiae, and plateau iris, among others.
  • Monocular status (fellow eye with visual acuity less than 20/100, or phthisical or enucleated/eviscerated fellow eye).
  • History of prior vitreoretinal surgery in either eye.
  • Pregnancy.
  • Inability to remain supine for the duration of testing.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 9/27/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Arthur Sit, M.D., M.S.

Open for enrollment

Contact information:

Bridgette Halder C.O.A.

(507) 422-2780

Halder.Bridgette@mayo.edu

More information

Publications

Publications are currently not available