Neurovascular Function in Women with Uterine Fibroids
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 22-002534
About this study
The purpose of this study is to determine if there is a connection between uterine fibroids and high blood pressure.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Premenopausal women, ages 18-50 years old.
- Uterine fibroid group (n≈20): These participants will have had a previous or current diagnosis of UF determined by ultrasound, hysteroscopy, or MRI, confirmed with medical documentation within one year of recruitment.
- Control (non-fibroid) group (n≈20): These participants will not have evidence of UF (confirmed by imaging) at the time of study participation.
Exclusion Criteria:
- History or evidence of:
- hepatic, renal, or hematological disease;
- peripheral vascular disease;
- stroke/neurovascular disease;
- diabetes;
- dyslipoproteinemia;
- hypertension (> 130/80 mmHg brachial cuff pressure);
- lung disease;
- arthritis affecting ability to exercise; or
- a body mass index > 30 kg/m^2.
- Participants also will be excluded if taking antihypertensive medication or medication that alters autonomic or vascular function (e.g., tricyclic antidepressants, alpha-blockers, beta-blockers, etc.).
- Participants will be non-smokers.
- Subjects must have a negative pregnancy test in order to participate in the study.
- Participants who are breastfeeding will be excluded.
- Women who have undergone hysterectomy will be excluded.
Eligibility last updated 3/7/22. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Sarah Baker, Ph.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available