Inclusion Criteria:

• ≥ 18 and ≤ 59 years of age.
• BMI ≥ 18.5.
• Indoor office workers employed full-time at the Mayo Clinic or another business within and around Rochester, MN.
• Report working a desk-based job, such as clerical and administrative staff.
• Fully vaccinated and boosted against COVID-19.
• Be willing to not wear a mask while in the office module.
• Allowed to work from home for at least a whole week (5 consecutive workdays in Background Work-from-Home Condition).
• Able to relocate to the WLL office during the workday, complete work in an open office space, be present for 80% of the total study for four consecutive work weeks, and be able to complete at least 80% daily tasks.
• Each workday, short personal meetings/calls and lunch break outside the office is allowed, but the participants should spend no less than 6 hours per day in the office.
• Be able to provide informed consent.

Exclusion Criteria:

• Individuals who are lactating, pregnant, or intend to become pregnant during the study.
• Shift-workers.
• Individuals who are taking medications (either prescribed or over-the-counter) which may affect mental status.
• Drug (illegal or prescription narcotic), nicotine, or alcohol dependency.
• Individuals diagnosed with pre-existing respiratory, neurological, or severe sleep disorders given their potential impact on study outcomes;.
• Individuals who have medical conditions associated with higher risk for severe COVID-19 (https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/16/23. Questions regarding updates should be directed to the study team contact.