Inclusion Criteria - Surveillance Population:

- Undergoing surveillance endoscopy for a diagnosis of non-dysplastic Barrett's
esophagus (NDBE, based on last endoscopic procedure; patients with prior history of
low-grade dysplasia/indefinite for dysplasia with NDBE at last endoscopy can be
included).

- Barrett's esophagus (BE) length of at least M1.

- English and Spanish speaking.

- Able to comprehend and complete the consent form.

- Age18-89 years.

- Life-expectancy of at least 2 years.

Inclusion Criteria - Screening Population:

- Undergoing endoscopy for screening of BE.

- BE length of at least M1.

- English and Spanish speaking.

- Able to comprehend and complete the consent form.

- Age 18-89 years.

- Expected life-expectancy of at least 2 years.

Inclusion Criteria - Physicians:

-All participating sites will include physicians who are trained in the use of WATS3D and
certified by the site PI. All endoscopists will need to complete a minimum of three cases
to be eligible to participate in the study.

Exclusion Criteria - Surveillance Population:

- BE patients undergoing surveillance or evaluation for endoscopic eradication therapy
(EET) for prior diagnosis of BE related dysplasia or esophageal adenocarcinoma (EAC).

- Active erosive esophagitis with LA Grade B or higher.

- Esophageal varices.

- Prior history of EET.

- Prior history of esophageal or gastric surgery, except for uncomplicated
fundoplication.

- Pregnancy.

Inclusion Criteria - Screening Population:

- BE patients undergoing surveillance or evaluation for EET for prior diagnosis for
BE-related dysplasia or EAC.

- Active erosive esophagitis with LA Grade B or higher.

- Esophageal varices.

- Prior history of esophageal or gastric surgery, except for uncomplicated
fundoplication.

- Pregnancy.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 9/12/22. Questions regarding updates should be directed to the study team contact.