Human Osteocalcin Gene Variant Functional Significance

Overview

About this study

The purpose of this study is to test if a rare variant in the osteocalcin protein may act as a gain of function mutation in this molecule.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:  

  • Individuals carrying the OSTEOCALCIN SNP gene and age, sex, and race matched controls.

Exclusion Criteria: 

  • Participants with a known diagnosis of type 1 or type 2 diabetes mellitus or those individuals on lipid lowering drugs, as these conditions may alter FGF21 and/or apolipoprotein B levels.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/25/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Sundeep Khosla, M.D.

Open for enrollment

Contact information:

Amanda Tweed

(507) 255-6663

Tweed.Amanda@mayo.edu

More information

Publications

Publications are currently not available