A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Overview

About this study

The purpose of this study is to evaluate the opioid dose-response on diaphragm muscle shear wave speed across breathing behaviors and respiratory function parameters in patients with no pre-existing respiratory conditions. We will directly evaluate if opioids decrease diaphragm muscle shear wave speed during higher force behaviors.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system).
  • Patients 18 years or older at time of surgery.

Exclusion Criteria: 

  • Patients who refuse research participation.
  • Patients who are pregnant.
  • Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Carlos Mantilla, M.D., Ph.D.

Open for enrollment

Contact information:

Heather Gransee Ph.D.

(507) 255-1999

Gransee.Heather2@mayo.edu

More information

Publications

Publications are currently not available