Inclusion Criteria:

* Adults \> 40 years of age
* Pain at the thumb base brought on by direct pressure (grind test) and with movement
* Pain resistant to previous conservative management with oral analgesics, NSAIDs, icing, and splinting
* Radiological observation indicative of arthritis based on the Eaton-Littler classification system (stages 1 through 4)
* Patient could understand the protocol and signed the informed consent
* Patient was covered by health insurance

Exclusion Criteria:

* Known allergy to either of the treatment products
* Patient's analgesic treatment regimen was modified within four weeks before trial inclusion
* Scaphoid-trapezial arthritis present
* Localized or systemic infection
* Previous thumb surgery on study thumb
* Previous thumb injury on study thumb
* Patient with inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis)
* Severe and/or uncontrolled hypertension
* De Quervain tendinopathy present
* Previous injections to the trapeziometacarpal joint on study thumb
* Uncontrolled diabetes
* Pregnant or lactating females
* Immunodeficient patients
* Patients that are currently using nicotine products, or who have quit in the last 12 months
* Patients under guardianship, curatorship, or are otherwise not self-sufficient
* Patients participating in another clinical research trial which interferes with this study protocol or outcomes
* Patients unable to follow the protocol in the investigators' judgement.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 6/25/2024. Questions regarding updates should be directed to the study team contact.