Von Willebrand Disease Natural History

Overview

About this study

The purpose of this study is to assess age-dependent increases in Von Willebrand Factor (VWF) levels in patients with Type 1 Von Willebrand Disease (VWD) and assess whether there is a change in a person’s bleeding symptoms that correlates with VWF levels.  In addition, we will assess whether certain molecular variants in VWF are more likely to be associated with age-dependent increases in VWF and subsequent changes in clinical bleeding.  

Findings from this study will provide us information that will lead to data driven management approaches for our increasingly growing population of patients with Type 1 VWD.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria: 

  • Patients with type 1 Von Willebrand Disease (VWD).

Exclusion Criteria: 

  • Unable to give informed consent or assent.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/2/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Meera Sridharan, M.D., Ph.D.

Open for enrollment

Contact information:

Meera Sridharan M.D., Ph.D.

Sridharan.Meera@mayo.edu

More information

Publications

Publications are currently not available