Effect of Fluctuations in Pressure on Human Performance

Overview

About this study

The purpose of this study is to investigate the potential contribution of rapid cabin pressure fluctuations to reported physiologic episodes (PEs). A new hypobaric chamber will be utilized to study the effects of the magnitude, frequency, and duration of pressure fluctuations on pilot physiology and cognitive performance. Multiple indicators of lung function, physiology, and cognition will be assessed. This work will help better define the conditions in which pressure fluctuations may lead to PEs and define criteria to evaluate environmental control systems and better protect pilots in tactical aircraft.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Healthy males and females between the ages of 18-50 years old.
  • Moderate- to- high fitness level and participate in regular physical activity.
  • Must have a body mass index (BMI) less than 30 kg/m^2.
  • Must be able to provide clear informed written consent.

Exclusion Criteria:

  • History of chronic respiratory, cardiovascular, metabolic disease or neural/cognitive disorders.
  • Anemia (< 12g/dl for males, < 1g/dl for females).
  • Active smoker (smoke within the past 6 years), or have more than 5 pack-years of smoking history.
  • Migraines.
  • Females who are pregnant or trying to become pregnant.
  • History of concussions, current absences or jaw pain or prior allergy to Afrin. 

Eligibility last updated 1/24/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Open for enrollment

Contact information:

Jordan Parks

(480) 301-6616

Parks.Jordan@mayo.edu

More information

Publications

Publications are currently not available