Loco-Regional Liposomal Bupivacaine Injection in Lower Extremity Revascularization

Overview

About this study

The purpose of this study is to compare loco-regional liposomal bupivacaine injection versus normal saline (placebo control group) to assess possible reduction of intra- and post- operative narcotic use with liposomal bupivacaine, in patients undergoing lower extremity revascularization.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • ≥ 18 years of age.
  • All males.
  • Females if sterile (history of tubal ligation or hysterectomy) and/or last menses was > 1 year ago.
  • Elective lower extremity revascularization is scheduled or being scheduled.

Exclusion Criteria:

  • Non-English speaking.
  • Chronic pain, currently requiring opioids.
  • On opioids greater than 1 weeks.
  • Allergy to local anesthetics.
  • Use of spinal or epidural for surgery.
  • Lack of patient cooperation.
  • Contraindication to regional anesthesia.
  • Vulnerable individuals.
  • Urgent/emergent surgeries.
  • Known to be pregnant or able to become pregnant.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/17/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Eau Claire, Wis.

Mayo Clinic principal investigator

Tiziano Tallarita, M.D.

Closed for enrollment

Contact information:

Joshua Druckrey C.N.A.

(715) 838-5831

Druckrey.Joshua@mayo.edu

More information

Publications

Publications are currently not available