Inclusion Criteria: 

• ≥ 35 and ≤ 75 years of age scheduled to undergo total knee arthroplasty (TKA), and prior history of osteoarthritis (OA).

Exclusion Criteria:

• Prior history of neurological disorders that affect their ability to walk or rise from a chair, cardiovascular problems that limit their ability to climb a flight of stairs or walk unassisted.
• Uncontrolled hypertension.
• History of cancer in the lower extremity.
• Rheumatoid arthritis.
• Thyroid disease.
• Hormone replacement therapy, and any other dysfunctions of the locomotor system that might influence performance during the sit-to-stand activity.
• Subjects with bilateral limb involvement will be allowed to participate in the parent study but will be excluded from this analysis if they had a prior arthroplasty surgery within the previous year; or plan to have an additional lower extremity arthroplasty.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 1/27/23. Questions regarding updates should be directed to the study team contact.