Magnetic Resonance Elastography pf Cognitive Impairment

Overview

About this study

The purpose of this study is to measure shear stiffness utilizing advanced Neuro Inversions (NNI) within cortical regions of the brain in patients with Alzheimer's Disease (AD). Also, to determine the relationship between brain stiffness and existing biomarkers including anisotropy in white matter tracts for AD, and to develop a joint mechanical-diffusion assessment of white matter health and its relation to vascular injury. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria: 

  • Human subjects will be recruited for the project from the Mayo Alzheimer’s Disease Research Center.
  • Cognitively normal elderly patients.
  • Patients with mild cognitive impairment.
  • Patients with Alzheimer’s disease.
  • Agse 18 to 100 years of age. 
  • Their dementia will not be due to other medical or psychiatric problems.

Exclusion Criteria:

  • Exclude individuals with contraindications to MRI scanning such as a cardiac pacemaker, the presence of intraocular or intracranial metallic objects and MRI incompatible devices.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 4/19/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

John Huston, M.D.

Open for enrollment

Contact information:

Timothy Waters

(507) 293-0692

Waters.Timothy@mayo.edu

More information

Publications

Publications are currently not available