Diagnostic and Prognostic Tissue-based Biomarker Assays for Inflammatory Dermatoses

Overview

About this study

Inflammatory dermatoses are sometimes difficult to diagnose with accuracy using current methods (clinical examination and routine skin biopsy). Targeted therapies (biologics) are available for severe inflammatory dermatoses, but selection of which particular biologic agent to use is often arbitrary. Trials of these medications are expensive and may be multiple before an effective treatment is found.
We propose to develop tissue-based biomarker assays for the diagnosis and therapeutic prognosis for inflammatory skin diseases.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults with immune-mediated dermatoses, as confirmed by retrospective chart review and skin biopsy.
  • Patients with available tissue blocks containing sufficient tissue for testing.

Exclusion Criteria:

  • Patients who decline to be involved in retrospective research on MN Research Authorization or have declined oral consent for inclusion in this specific study.
  • Lack of inclusion criteria.

Eligibility last updated 1/4/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Julia Lehman, M.D.

Closed for enrollment

Contact information:

Fangyi Xie M.B., B.CH.

(507) 293-0363

Xie.Fangyi@mayo.edu

More information

Publications

Publications are currently not available