Inclusion Criteria:

- Patient has suspected or confirmed metastatic cancer within the lungs, or stage IV
non-small cell lung cancer (NSCLC) requiring biopsy.

- Patient has radiologically documented suspected, or confirmed tumor(s) that are ≤ 5 cm
in longest diameter and deemed by the investigator to be suitable per study procedural
guidelines for treatment with PEF.

- Patient is deemed eligible to receive 1L SOC therapy for their malignancy.

- In the opinion of the investigator, the patient is not a surgical candidate for
curative intent, or the patient has refused surgery.

- Life expectancy ≥ 6 months.

Exclusion Criteria:

- Patient has received any prior cancer therapy for current tumor(s) to be treated with
PEF.

- Patient is scheduled to receive investigational therapies (including device-based
therapy) that may interfere with the study endpoints while on this study.

- Patient has clinical evidence of leptomeningeal disease or brain metastases that
require SOC treatment within 4 weeks post-PEF treatment.

- Patient with active, known, or suspected autoimmune disease.

- Patient with type I diabetes mellitus, hypothyroidism only requiring hormone
replacement, skin disorders (such as vitiligo, psoriasis, or alopecia) not requiring
systemic treatment, or conditions not expected to recur in the absence of an external
trigger are permitted to enroll.

- Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency) is not considered a form
of systemic treatment and is allowed.

- Patient has received systemic treatment with corticosteroids (> 10 mg daily prednisone
or equivalent) or other immunosuppressive medications within 30 days prior to study
enrollment. Inhaled or topical steroids, and adrenal replacement doses > 10 mg daily
prednisone or equivalent are permitted in the absence of active autoimmune disease.

- Patient has any history of primary immunodeficiency.

- Patient has clinical signs or symptoms of active tuberculosis infection.

- Patient has documented evidence of acute hepatitis or has an active or uncontrolled
infection.

- Patient has undergone major surgery (excluding placement of vascular access) within 28
days prior to study enrollment or has planned major surgeries while enrolled in the
study,

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/13/24. Questions regarding updates should be directed to the study team contact.